منابع مشابه
P 133: Neuroinflammation in Alzheimer ’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common form of dementia. Almost 47 million people suffer from dementia worldwide. AD accounts for approximately 60%–80% of all dementia cases. Three major pathologies characterize the disease: senile plaques, neurofibrillary tangles and inflammation. We review the literature on events contributing to the inflammat...
متن کاملNeuroinflammation in Alzheimer’s disease
Amyloid-β plaques and neurofibrillary tangles are the main neuropathological hallmarks in Alzheimer's disease (AD), the most common cause of dementia in the elderly. However, it has become increasingly apparent that neuroinflammation plays a significant role in the pathophysiology of AD. This review summarizes the current status of neuroinflammation research related to AD, focusing on the conne...
متن کاملNeuroinflammation in Alzheimer's disease.
Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute...
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Osteopontin also known as bone sialoprotein (BSP). Osteopontin role as a linking protein. it is an extracellular structural protein and therefore an organic component of bone. Osteoprontin (OPN) binds to several integrin receptors containing α4β1, α9β1, and α9β4 expressed by leukocytes. These receptors have been well-stable to function in cell adhesion, migratio...
متن کاملNeuroinflammation in motor neuron disease
Increasing evidence suggests that the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) is not restricted to the neurons but attributed to the abnormal interactions of neurons and surrounding glial and lymphoid cells. These findings led to the concept of non-cell autonomous neurodegeneration. Neuroinflammation, which is mediated by activated glial cells an...
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ژورنال
عنوان ژورنال: Journal of Neuroimmune Pharmacology
سال: 2009
ISSN: 1557-1890,1557-1904
DOI: 10.1007/s11481-009-9176-0